Methotrexate, Inhibiting Folate Metabolism to Impair Cell Growth
Introduction Many pharmaceutical drugs work by inhibiting specific enzymes in metabolic pathways. One example is methotrexate, which is a chemotherapeutic drug used to treat certain cancers as well as autoimmune diseases like rheumatoid arthritis (Shiroky, 1997). Methotrexate is a synthetic drug that functions as an antimetabolite. The mechanism of action of methotrexate involves the competitive ... Read More
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